Cross-referenced: 23andMe (160+ SNPs) · Rythm Health Labs (Apr 2026) · Prenuvo MRI · Fountain Life · Viome · Eight Sleep
| # | Supplement | Primary Organ | Why It Matters For Carlos | Lab/Genetic Evidence |
|---|
| 1 |
Omega-3 Fish Oil (4g/day) |
🫀 Heart + 🧠 Brain |
FADS1/FADS2 variants mean you can't efficiently convert plant omega-3 (ALA) to EPA/DHA. Direct fish oil is essential. Lowers TGs, supports cardiac membrane integrity, and provides neuroprotection. |
FADS1 GT · FADS2 CG · TGs 131 (was 329) · LDL 133.4 ⚠️ |
| 2 |
CoQ10 Ubiquinol (400mg/day) |
🫀 Heart + ⚡ Mitochondria |
ACE DD + ENOS GT = vascular double-hit. CoQ10 fuels the electron transport chain in every cell, but especially heart muscle. Supports blood pressure regulation and energy production at the cellular level. |
ACE DD · ENOS GT · RHR 49 bpm ✅ · BP needs monitoring |
| 3 |
Vitamin D3 (5,000 IU) |
🦴 Bones + 🛡️ Immune |
Triple impairment: CYP2R1 AG + GC AC + VDR variants all slow your D3 pathway. You went from deficient (29) to optimal (64.4) — this dose maintains it. Critical for bone density (L5/S1 degeneration) and immune modulation. |
CYP2R1 AG · GC AC · VDR · Vit D: 29→50→38→64.4 ✅ |
| 4 |
Vitamin K2 MK-7 (200mcg) |
🦴 Bones + 🫀 Arteries |
K2 is the "traffic cop" for calcium — directs it INTO bones and AWAY from arteries. With your high LDL/ApoB, preventing arterial calcification is critical. Works synergistically with D3 and your COL1A1 TT bone vulnerability. |
CETP GG · COL1A1 TT · ApoB 108 ⚠️ (↓21%) · DEXA Z-score -0.3 |
| 5 |
Curcumin Meriva (1g/day) |
🫘 Liver + 🔥 Systemic |
IL-6 GC + IL-6R AC = genetic inflammation double-hit. Curcumin is the most potent natural IL-6 suppressor. Supports liver clearance of metabolic waste and helps keep hs-CRP at its current excellent level (<0.5). |
IL-6 GC · IL-6R AC · hs-CRP <0.5 ✅ · Liver fat was 7.3% |
| 6 |
NAC (600mg) |
🫘 Liver + 🫁 Lungs |
GSTM1 DELETED = your Phase II liver detox pathway is missing. NAC is the precursor to glutathione (master antioxidant), compensating for this genetic gap. Also protects lung tissue and supports liver processing of TRT metabolites. |
GSTM1 DELETED · SOD2 AG · ALT 45 (was 57) · T >1500 |
| 7 |
Methylated B-Complex |
🧠 Brain + 🫘 Liver |
MTHFR 677 CT = 35% reduced methylation capacity. Methylated B vitamins bypass this bottleneck, ensuring proper homocysteine clearance (yours improved: 8.5→7.2), neurotransmitter synthesis, and DNA repair. |
MTHFR 677 CT · Homocysteine 7.2 ✅ · B12 730 ✅ · Folate >20 ✅ |
| 8 |
L-Tyrosine (500mg) |
🧠 Brain (Dopamine) |
DRD2 TT = 30% fewer dopamine receptors. Tyrosine is the direct precursor to dopamine. Supports focus, motivation, and cognitive resilience — especially important during high-stress periods. |
DRD2 TT · MAOA TT (warrior gene) · COMT GA |
| 9 |
CDP-Choline (500mg) |
🧠 Brain (Memory) |
MTHFD1 GA = higher choline demand. Choline is essential for acetylcholine (memory neurotransmitter) and cell membrane integrity. Your genetics require 550mg+/day — diet alone won't cover it. |
MTHFD1 GA · HIGH choline demand · Nutrient demand: 🔴 HIGH |
| 10 |
Calcium Citrate (500mg) |
🦴 Bones |
COL1A1 TT = collagen gene variant affecting bone matrix quality. Combined with your L5/S1 disc degeneration (Prenuvo), calcium supports structural integrity. Citrate form for better absorption. |
COL1A1 TT · L5/S1 bulge + 25% height loss · DEXA Z -0.3 |
| 11 |
Collagen Peptides (10g) |
🦴 Joints + 🧬 Connective Tissue |
Triple joint vulnerability: COL1A1 TT + MMP1 + GDF5 TT. Collagen peptides provide the raw building blocks for cartilage, tendons, and disc repair. Directly addresses your Prenuvo spinal findings. |
COL1A1 TT · MMP1 · GDF5 TT · L5/S1 annular fissure |
| 12 |
Creatine Monohydrate (5g) |
🧠 Brain + 💪 Muscle |
ACTN3 XX = endurance genotype (no fast-twitch protein). Creatine enhances ATP recycling for both cognitive performance and your high-volume daily activity (22K steps avg). Also neuroprotective. |
ACTN3 XX · Steps: 22,353/day · VO2 Max 42.2 |
| 13 |
L-Carnitine ALCAR (1g) |
🫀 Heart + ⚡ Mitochondria |
ADRB2 GG/GG = fat cells are "deaf" to adrenaline. L-Carnitine physically transports fatty acids into mitochondria to be burned. This is the shuttle that forces your resistant fat cells to release energy. |
ADRB2 GG/GG · PPARA GC · Fat storage: 🔴 VERY HIGH risk |
| 14 |
DIM (200mg) |
🫘 Liver + ⚖️ Hormones |
CYP19A1 TT = high aromatase activity (converts testosterone → estrogen). DIM promotes the "good" 2-OH estrogen metabolite pathway in the liver, helping clear excess E2. Critical with your T >1500 and E2 58.9. |
CYP19A1 TT · E2 58.9 🔴 · T >1500 |
| 15 |
Calcium D-Glucarate (500mg) |
🫘 Liver (Phase II Detox) |
UGT2B15 TG = impaired estrogen glucuronidation (clearance). Ca-D-Glucarate inhibits beta-glucuronidase, preventing reabsorption of estrogen your liver already processed. Works with DIM as a 1-2 punch. |
UGT2B15 TG · E2 climbing: 28→47.6→58.9 |
| 16 |
Selenium (200mcg) |
🦋 Thyroid |
DIO2 TC = reduced conversion of T4 → active T3. Selenium is a cofactor for deiodinase enzymes. You went from subclinical hypothyroid (TSH 5.03) to optimal (1.27) — selenium helps maintain this. |
DIO2 TC · TSH: 5.03→1.06→1.55→1.27 ✅ |
| 17 |
Glucosamine/Chondroitin |
🦴 Joints + 🦿 Cartilage |
GDF5 TT = joint/cartilage vulnerability gene. Directly provides the building blocks for cartilage repair and synovial fluid. Addresses the L5/S1 disc degeneration and protects all joints given your 22K daily steps. |
GDF5 TT · L5/S1 disc bulge · 22K steps/day · ACTN3 XX |
| E1 |
Magnesium Glycinate (400mg) |
🫀 Heart + 🧠 Brain + 💤 Sleep |
ACE DD (BP) + GABRA2 AG + GAD1 CT (impaired GABA/calm signaling). Magnesium glycinate crosses the blood-brain barrier, calms the nervous system, supports deep sleep (your 18% deep sleep), and helps regulate blood pressure. |
ACE DD · GABRA2 AG · GAD1 CT · Deep sleep 77min (18%) |
| E2 |
Berberine (500mg) |
🫘 Liver + 🩸 Blood Sugar |
IRS1 CT = reduced insulin signaling. Berberine activates AMPK (the "exercise mimetic" enzyme), improves insulin sensitivity, and has statin-like LDL-lowering effects. Targets both your insulin history and current LDL 133.4. |
IRS1 CT · Insulin: 23.6→8.7 ✅ · LDL 133.4 ⚠️ |
